How can we safely get that extra pep at the gymnasium. The candidates are...
- Anavar
- HGH (Human growth hormone) using MK677
- Cardarine
- Stenabolic
The remodeling of the human body is endocrine effect, signalled using androgens and growth factors. Both androgens and growth factors decline with age, diminishing grunt and gains. For example, after the age of 20-30, HGH levels decline 14-15% every 10 years; by the age of 60 HGH is usually less than half what it was at 25. At 20 the pituitary gland produces about 500 mg/day, at 40 down to 200 mg/day, and at 60 down to 25 mg/day. Bringing these with the higher levels of physiological ranges on training days. Testosterone decreases and grunt levels go down making gym work harder. Bone strength and muscle strength also decrease leading to frailty. We have pushed for a general anti-frailty safe drug for the elderly in conjunction with gymnasium, low dose anavar, ostarine on training days only are possible candidates, along with educating society that gym work is essential, high intensity training (HIT) regardless of age.
We are utilizing Mike Mentzer's HIT (high intensity training) which specifies maximum intensity followed by 5 or 7 days rest afterward. The "drug holiday" means safer use, non-suppression. For example, if we are to do a full body HIT session on Sunday using 25mg Anavar, possibly split, arms, shoulders and chest in the morning and legs and back after lunch, with the next usage of Anavar 5 days later and all rest days in between. We could utilize MK677, Caradarine, Stenabolic, none of which are suppressive. For example, we may utilize MK677 to aid in recovery and possibly the Stenabolic for a cardio session. We are not exceeding physiologic levels in any of these drugs, and we are allowing sufficient time for the drug to be cleared from the system and for the normal state to return. Staying within physiological levels means the gains can be maintained by the natural biology. i.e we accept the modest pep, and be patient.
Anavar
Generally safe oral anabolic drug. Causes suppression of natural testosterone with cycle. Very mild.
Purported Benefits
- Strength gains
Purported Drawbacks
- Suppression of natural testosterone production
- Cholesterol, may increase your risk of heart or blood vessel problems (coronary artery disease).
My experience: Anavar does NOT provide pep in the gym. Anavar seems to be better suited post workout as a recovery. Anavar does not provide more power in the lifting session resulting in more activation, instead a general natural session of sufficient intensity to create the inflammation where post workout Anavar ensures enough anabolic to maximize muscle growth. The strength gain is felt in the next session. The proposed dose is post workout with the protein, where the body begins building muscle. Not every day, instead a single dose only. Depending on the grade of Anavar a maximum dose is provided and slowly titrate there and do not exceed the maximum dose. No suppression occurred with the regimen because of the large lull in between usage.
Just a note of high intensity, immune system decline with aging combined with high intensity exercise can lead to a immune comprised state and respiratory disease.
HGH using MK677
Ways of stimulating HGH, high amino acid levels, low glucose levels and low fatty acid levels in the blood, exercise and with a drug. MK677 is a research chemical not approved for human use, in use among bodybuilders. Benefits of healthy HGH levels are...
- Loss of body fat
- Muscle growth
- Bone growth, tougher bones, fracture healing
- Increased energy levels and exercise capacity
- Possible improvement to physical condition
- Possible improvement to immune system
Purported Drawbacks of HGH
- Increase IGF-1 levels - anabolic state, over-active AMP and protein synthesis and reduced lifespan conversely the catabolic state, mTor authophagy and under-active AMP and protein synthesis and increased lifespan. 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain, regenerative vs proliferative factors and effects persist beyond administration which suggests theoretically that one need not chronically raise IGF1 every day to benefit. It is an anabolic and implicated with shorten lifespan.
- Left ventricular hypertrophy.
- Mitral valve prolapse (general heart remodelling associated with androgen use), Androgens are known to target muscle cells by promoting their growth and cardiomyocytes can respond to testosterone by increasing the cell size leading to cardiac hypertrophy.
- Increased size of organs with high doses.
Hormone therapy TRT or HRT requires injections as the molecules are too big to pass the small intestine, described here are the only known means of oral supplementation of hormones.
- How do I properly use HGH? What dosage should I take?
- Growth Hormone and Aging: Updated Review
There is an effort to stop bone and muscle decline with age as a treatment for aging, all without adverse health consequences of supposed medication. The best candidates are a Myostatin inhibitor, Ostarine MK-2866, Anavar (not both) in conjunction with high intensity gym work. Frailty has also been associated with the aging immune system. A safe anti-frailty pill disregarding life extension and even accepting shortening lifespan in exchange for higher quality of life is not allowed, the aged are forgotten and barred from helping themselves.
While Anavar has a proven safety record, Ostarine MK-2866 has recently shown efficacy against loss of muscle mass and function (sarcopenia) and loss of bone mass (osteopenia or osteoporosis) occurs with advancing age, when untreated, represent a major public health problem for the elderly population and may result in loss of independence in later life. Both these conditions are a cause of accidents and hip replacements and may prove avoidable if a safe steroid like Ostarine is deemed safe.
Dosages against sarcopenia and osteoporosis are not dosages used in bodybuilding, its highly dose dependent, the higher the doses the greater the risks. Chronic high doses of steroids in bodybuilding is linked to cardio vascular disease, CVD, heart attacks, enlarged hearts and plaque blockages, coronary artery disease, it also destroys liver, kidneys and pancreas and likely more. However, at the correct dose, restoring endogenous levels, there are instead health benefits, these correct doses generally do not exceed those naturally present in a 20-30 year old person while bodybuilders have known to inject 100 times those amounts daily. The possibility of safe use and benefits cannot be measured by use in bodybuilding.
Selective Androgen Receptor Modulators (SARMs), orally bio-available with most still in clinical research stage. SARMs mimic the effects of hormones, the most popular SARMs currently include Ostarine (Enobosarm, MK2866, S22), S23, Ligandrol (LGD-4033), LGD-3033, TT-701, Testolone (RAD-140), and Andarine (GTx-007, S-4), SR9009 (Stenabolic), Ibutamoren (MK-677, Nutrabol) (a segretagogue not a SARM), GW501516 (GW1516, Cardarine, Endurobol), YK-11. SARMS are mainly targeted towards building muscle and bone density without androgenic effects. SR9009 differs as it facilitates weight loss. SR9009 and the newer more bio-available SR-9011 has the ability to make your body respond as if it were in a state of constant exercise, increasing the basal metabolic rate and also modifies mitochondria.
Ibutamoren (MK-677, Nutrabol), is a human growth hormone (HGH) secretogogue. It is a gherlin agonist causing the pituary gland to produce more growth hormone. Human growth hormone has been associated with many health benefits, increased HGH comes with increase in IGF-1, Insulin like growth factor one levels. Rise in insulin is associated with shortened lifespan and associated with the Western diet, cadiovascular disease and diabetes. High levels of IGF-1 is also believed to shorten lifespan.
MK-677, reports the growth hormone releasing hormone GHRH (MK677) Ibutamoren may get suppressed, desensitized after some months of use as the hypothalamus senses and increases somatostatin 1. The conclusion reads quote: Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST (somatostatin) in the hypothalamus. Further studies are needed to overcome the observed desensitization.
Brand name: Macrilen or macimorelin is a growth hormone (GH) secretagogue receptor agonist indicated for the diagnosis of adult growth hormone deficiency. It is FDA approved for the diagnosis of HGH deficiency only and not approved for long term use. https://www.drugs.com/history/macrilen.html
We require to manage these issues towards a safe protocol.
- Manage increased IGF-1 levels.
- Manage somatostatin.
- Left ventricular hypertrophy, is a thickening of the wall of the heart's main pumping chamber. This thickening may result in elevation of pressure within the heart and sometimes poor pumping action. The most common cause is high blood pressure. Log your blood pressure and if it rises with HGH use, lower the dosage or cease use. It is unknown what dose may lead to LVH. Bodybuilders are taking 100 times normal doses of many substances, and they suffer heart attacks and organ failure in their late 20s onwards, clearly shortening lifespan. Dosage is important, too little and no action, too much and chronic use and complications so it is believed that doses kept within normal, those not exceeding 20-30 year olds are safe. It may be possible that a sweet spot dose is surpisingly beneficial to heart function noted from heart function of GH deficient versus heart function related to bodybuilders. Acromegaly shows LVH vs. GHD Growth Hormone Deficient supplementation shows no LVH.
- Growth hormone status predicts left ventricular mass in patients after cure of acromegaly
- Controversies Regarding the Effects of Growth Hormone on the Heart
- Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure
- Growth hormone: a newcomer in cardiovascular medicine
- Is growth hormone good for the heart?
- Cardiovascular effects of high-dose growth hormone treatment in growth hormone-deficient children