Human Growth Hormone (HGH) and Dehydroepiandrosterone (DHEA) are the two popular anti-ageing hormones, both decline with age and have been associated with major health benefits. After the age of 20-30 HGH levels decline 14-15% every 10 years; by the age of 60 HGH is usually less than half what it was at 25. At 20 the pituitary gland produces about 500 mg/day, at 40 down to 200 mg/day, and at 60 down to 25 mg/day. The bio-hack is to maintain HGH at 20-30 age range levels, as over 30's are neither growing as a child nor pubescent. Both these hormones are orally bio-available, no injections.
Purported Benefits of HGH
Loss of body fat
Bone growth, tougher bones, fracture healing
Increased energy levels and exercise capacity
Possible improvement to physical condition
Possible improvement to immune system
Purported Drawbacks of HGH
Increase IGF-1 levels - anabolic state, over-active AMP and protein synthesis and reduced lifespan conversely catabolic state, mTor authophagy and under-active AMP and protein synthesis and increased lifespan. 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain, regenerative vs proliferative factors and effects persist beyond administration which suggests theoretically that one need not chronically raise IGF1 every day to benefit. It is an anabolic and implicated with shorten lifespan, so you have to follow up with mTor inhibition and autophagy.
Left ventricular hypertrophy.
Mitral valve prolapse (general heart remodelling associated with androgen use), Androgens are known to target muscle cells by promoting their growth and cardiomyocytes can respond to testosterone by increasing the cell size leading to cardiac hypertrophy
Increased organ size with high doses.
Purported Benefits of DHEA
Benefits related to increases in testosterone and estrogen
Approved for vaginal atrophy
Purported Drawbacks of DHEA
Hormone therapy TRT or HRT requires injections as the molecules are too big to pass the small intestine, described here are the only known means of oral supplementation of hormones specifically HGH as Ibutamoren (MK-677, Nutrabol) as capsules still a research molecule, Testosterone as Ostarine as capsules still a research molecule or DHEA as capsules which have been available for many years.
DO NOT ABUSE THE DRUGS. If you are too compulsive please do not take drugs.
There is an effort to stop bone and muscle decline with age as a first treatment of ageing all without adverse health consequences of supposed medication. It is possible and the best candidates either Myostatin inhibitor or Ostarine MK-2866 (not both) with Ostarine in conjunction with gym favourable. Frailty has also been associated with the aging immune system.
An safe anti-frailty pill disregarding life extension and even accepting shortening lifespan in exchange for higher quality of life is not allowed, the aged are forgotten and barred from helping themselves.
Ostarine MK-2866 has recently shown efficacy against loss of muscle mass and function (sarcopenia) and loss of bone mass (osteopenia or osteoporosis) occurs with advancing age, when untreated, represent a major public health problem for the elderly population and may result in loss of independence in later life. Both these conditions are a cause of accidents and hip replacements and may prove avoidable if Ostarine still in clinical trials is deemed safe, requires gym exercise to build extra muscle and bone.
Dosages against sarcopenia and osteoporosis are not dosages used in bodybuilding, the higher the doses the greater the risks. Chronic high doses of steroids in bodybuilding is linked with CVD, heart attacks, enlarged hearts and plaque blockages, coronary artery disease, it also destroys liver, kidneys and pancreas and likely more. However, at the correct dose, restoring endogenous levels, there are instead health benefits, these correct doses generally do not exceed those naturally present in a 20-30 year old person while bodybuilders have known to inject 100 times those amounts daily. The possibility of safe use and benefits cannot be measured by use in bodybuilding.
The avoidance of hormone therapy was always injections, and the industry has searched to make hormones orally bio-available such as CriticalSorb™ with reported bio-availability of HGH at 49% obtained in the first 2 hours after administration by nasal (1). Unknown how long term use might affect nasal mucosa. The next best was 11.06% in Sprague-Dawley rats (not humans) and some other methods 3.4%. (all relative to sub-cutaneous)
Selective Androgen Receptor Modulators (SARMs), orally bio-available with most still in clinical research stage. SARMs mimic the effects of hormones, the most popular SARMs currently include Ostarine (Enobosarm, MK2866, S22), S23, Ligandrol (LGD-4033), LGD-3033, TT-701, Testolone (RAD-140), and Andarine (GTx-007, S-4), SR9009 (Stenabolic), Ibutamoren (MK-677, Nutrabol) (a segretagogue not a SARM), GW501516 (GW1516, Cardarine, Endurobol), YK-11. SARMS are mainly targeted towards building muscle and bone density without androgenic effects. SR9009 differs as it facilitates weight loss. SR9009 has the ability to make your body respond as if it were in a state of constant exercise, increasing the basal metabolic rate and also modifies mitochondria.
Ibutamoren (MK-677, Nutrabol), is a human growth hormone (HGH) secretogogue. It crines the pituary gland to produce more growth hormone. Human growth hormone has been associated with many health benefits, increased HGH comes with increase in IGF-1, Insulin like growth factor one levels. Rise in insulin is associated with shortened lifespan and associated with the Western diet, cadiovascular disease and diabetes. IGF-1 is also believed to shorten lifespan.
MK-677, reports the growth hormone releasing hormone GHRH (MK677) Ibutamoren may get suppressed, desensitized after some months of use as the hypothalamus senses and increases somatostatin 1. The conclusion reads quote: Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST (somatostatin) in the hypothalamus. Further studies are needed to overcome the observed desensitization.
Brand name: Macrilen or macimorelin is a growth hormone (GH) secretagogue receptor agonist indicated for the diagnosis of adult growth hormone deficiency. It is FDA approved but untested. https://www.drugs.com/history/macrilen.html
We require to manage these issues towards a safe protocol.
Manage increased IGF-1 levels.
Left ventricular hypertrophy, is a thickening of the wall of the heart's main pumping chamber. This thickening may result in elevation of pressure within the heart and sometimes poor pumping action. The most common cause is high blood pressure. Log your blood pressure and if it rises with HGH use, lower the dosage or cease use. It is unknown what dose may lead to LVH. Bodybuilders are taking 100 times normal doses of many substances, and they suffer heart attacks and organ failure in their late 20s onwards, clearly shortening lifespan. Dosage is important, too little and no action, too much and chronic use and complications so it is believed that doses kept within normal, those not exceeding 20-30 year olds are safe. It may be possible that a sweet spot dose is surpisingly beneficial to heart function noted from heart function of GH deficient versus heart function related to bodybuilders. Acromegaly shows LVH vs. GHD Growth Hormone Deficient supplementation shows no LVH.
Take account of sugar intake, which is hidden is almost every product in the supermarket, to compensate for the increase in IGF-1. The worst diet is malnutrition, the second-worst diet is the western diet. The western diet is a high insulin requirement diet and mimics the diabetic state. High insulin diets cause heart attacks, strokes, (CVD cardiovascular disease), organ failure, diabetes. A low insulin requirement diet therefore is preventative against all cause mortality. Opting towards a low insulin requirement diet will increase health span and life span, the western diet and diabetes is crystal clear about this. Insulin is not the bad guy, it is an indicator of too much sugar too quickly, eating way too much and overloading your organs and cells.
Taking HGH (MK-677) causes an increase in insulin like growth factor 1 (IGF-1) levels for 24 hours after administration. We need to understand how much insulin we are producing and how much IGF-1 we are producing. We can no longer have ignorant crazy soda spikes every hour or thousands of calories in 5 minutes. HGH works with IGF-1 and insulin to remodel the body. How much protein and sugars do we want to give the anabolic state? And do so in the healthiest way possible with the lowest load on the organs.
Sugar in the blood, is really about blood composition and not altering blood composition significantly through diet. There are several other substances that are just as poisonous and dangerous as fast digesting sugars. So if we are going to run IGF-1, we do not need to run simple sugars as well.
A low insulin requirement diet is believed to extend lifespan to its maximum by itself. You must get this right and understand what is being stated here.
Diabetics have permanent raised insulin levels.
Diabetics have high blood sugar levels. High sugar levels in the blood destroy the body.
High insulin requirements have been associated with shorten lifespan.
Insulin resistance has been associated with diabetes, stroke, heart attacks, multiple organ disease and failure, and more.
Insulin is NOT just about sugar, all foods except water trigger the production of insulin.
Understanding blood composition changes from diet is the basis for running supplements and drugs safely.
Sugar that is digested slowly, complex carbohydrates, such as legumes are perfectly healthy. The pancreas is not inundated beyond its capacity and excess sugar does not circulate destroying the body while waiting to be processed by a pancreas that cannot keep up with the workload.
What is the minimum amount of food that is a nutritionally complete diet. Eat at one sitting.
Be nutritional complete, vitamins, minerals, amino-acids using the lowest glycaemic index and insulin index foods only. Do not be in malnutrition, do not eat in excess.
Time restriction eating, be on an 20/4, 18/6, 16/8 eating window, so that organs can rest during off time and overnight.
Eat only foods that are a single ingredient. When you look at the ingredients label, it should only be 1 ingredient. These are the foods that exist in nature, and the name of the food is usually the same name as the ingredient.
Eliminate secretly added sugars, fructose, out of the diet. Once a fruit is processed, the fruit juice is basically sugar. Modified fruits by selective farming may now be unhealthy and may have been bred to be high GI food. As a result, not all fruits are healthy. Eliminate refined carbohydrates, when raw wheat or rice is refined, the result is basically sugar.
Avoid foods that drive inflammation. The new sugar is vegetable oil, eliminate oils from the diet and there are many more poisons in so called food, air and environment.
Perform insulin resistance reversing practices such as exercise.
The insulin index and to a lessor extent the glycaemic index are the authority on low insulin requirement diet, stay out of hypoglycaemia, hypoglycaemia, and insulinemia. Insulin Index, a low glycaemic diet may still be a high insulin diet.
Enjoy lifelong work on personal nutrition.
It can take up to 12 months to reverse insulin resistance, after many years doing it to urself.
The production of IGF-1 is done by the liver and the production of insulin is done by the pancreas.
Our periodic use of MK-677, 25 mg, once per 7 days or once every 5 days. This is done 1 hour prior to hitting the gymnasium, in conjunction with strength and cardio training. Use other PEDs for subsequent gym session days such as MK-2866 or DHEA. Getting some PEP in the gymnasium with aging is everything. Allow the human body some days to return to normal.
Certain activities raise HGH naturally (1). The two major activities is high intensity exercise, sleep and intermittent fasting.
DO NOT ATTEMPT THIS IF YOU DID NOT UNDERSTAND THE INSULIN - IGF-1 SITUATION
Discontinue use or lower dosage with side effects.
People that take PED's do blood tests to monitor their levels and keep them in the normal ranges.
Blood glucose monitors are popular, such a product is gluco-wise, https://gluco-wise.com/, these measure blood sugar levels. It provides a proof that the diet is not spiking blood sugar. Diabetic use A1C test is a long term test of blood sugar. The dosage and frequency of safe MK-677 usage is limited by insulin and IGF-1 levels. Measuring IGF-1 levels cannot be done at home. The IGF-1 Blood Test is also known as SM-C/IGF-1, Somatomedin-C, and Sulfation Factor. No fasting is required for this test, unless instructed to fast 10 to 12 hours before, and results will be delivered within 1-2 days. Some home tests similar to finger prick has been seen online but never tried.
A fasting blood glucose test will show your fasting blood sugar level. You'd have this test done after not eating or drinking for at least eight hours. Fasting blood sugar levels under 100 milligrams/decilitre (mg/dL) are considered normal. Levels between 100 and 125 mg/dL indicate prediabetes. Levels equal to or greater than 126 mg/dL are diagnostic for diabetes. These numbers could vary up to 3 mg/dL points in the cut-off numbers. You will also want to test your meals for healthy insulin waveforms and not spikes and change out foods and beverage to improve performance.
Two-hour glucose tolerance test, your blood glucose level is determined before this test begins. You then receive a pre-measured sugary drink and your blood glucose level is checked again in two hours. A blood sugar level after two hours of less than 140 mg/dL is considered normal. A result between 140 mg/dL and 199 mg/dL is considered prediabetes. A blood sugar level of 200 mg/dL or higher is considered diabetes.
Low blood sugar (hypoglycaemia): sweating, feeling tired, dizziness, feeling hungry, tingling lips, feeling shaky or trembling, a fast or pounding heartbeat (palpitations), becoming easily irritated, tearful, anxious or moody, turning pale. Further on, weakness, blurred vision, confusion or difficulty concentrating, unusual behaviour, slurred speech or clumsiness (like being drunk), feeling sleepy, seizures or fits, collapsing or passing out.
High blood sugar (hyperglycaemia): increased thirst and a dry mouth, needing to pee frequently, tiredness, blurred vision, unintentional weight loss, recurrent infections, such as thrush, bladder infections (cystitis) and skin infections, tummy pain, feeling or being sick, breath that smells fruity
HGH makes children grow so the side effects of taking HGH could be joint and muscle pain, increased insulin resistance, swelling in the arms and legs, for men enlargement of breast tissue (gynaecomastia), carpal tunnel syndrome. If you notice any of these then discontinue use. My personal side effects, body pains, joint pains momentary or pulsing, kept awake all day while feeling tired all day, good mental state but apathetic, cold hands or cold feet, disinterested, disorientated, discomfort to focus, prefer to lay down, stomach discomfort or upset, diarrhoea.
Shows typical results of dose of MK-766 in HGH and IGF-1 levels, overlay with your age. Indicates a dose between 2mg and 10mg. The 2mg dose might still produce a early spike but low dose is easily cleared from the body before 24 hours.
In the present study, to increase the oral bioavailability of growth hormone and improve patient compliance, enteric-coated capsules filled with monomethoxyl poly(ethylene glycol)-b-poly(L-lactide-co-glycolide) nanoparticles were prepared to facilitate oral growth hormone delivery. The nanoparticles were less than 100 nm in size, exhibited narrow polydispersity indices < 0.3, and showed a zeta potential of -4.87 mV. The highest efficiency of growth hormone encapsulation achieved in this study was nearly 70%. An in vitro release experiment showed that adequate amounts of growth hormone were retained under simulated gastric conditions and significant amounts of growth hormone were released under simulated intestinal conditions. The bioavailability of encapsulated growth hormone relative to subcutaneously injected growth hormone in Sprague-Dawley rats was 11.06%. Thus, the use of poly(ethylene glycol)-b-poly(L-lactide-co-glycolide) nanoparticles yielded promising results, and these agents should be investigated further regarding their potential as an oral growth hormone delivery system in the future.
Liposomes for the oral delivery of human growth hormone (hGH) containing bio-enhancers and tetraether lipids were prepared by dual asymmetric centrifugation. Cetylpyridinium chloride (CpCl), d-α-tocopheryl polyethylene glycol 400 succinate, phenylpiperazine, sodium caprate or octadecanethiol were used as permeation enhancers. In vitro data showed that oligolamellar vesicles with average size in the range of 200-250 nm were formed. Performance of the formulations was investigated both ex vivo by confocal microscopy scans of sections of rat small intestine and in vivo by comparing the area under the plasma curve of hGH after oral or subcutaneous (s.c.) application. The microscopic data reveal an interaction between the liposomal formulation and the intestinal mucus layer. Particularly one formulation, which was designed to be mucus penetrative by addition of a high quantity of TPGS 400 and a ζ-potential close to 0 mV, showed a very strong mucus association in the duodenum and jejunum. Vesicles with CpCl 33% (mol/mol) led to a relative hGH bioavailability of 3.4% compared with s.c. control, whereas free hGH administered orally showed a bioavailability of only 0.01%.
Suggests that MK-677 stops working after a period of use...
Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I. At 6 weeks after treatment, the GH response to MK-677 was abolished. Pituitary GH mRNA and hypothalamic GH-releasing hormone mRNA, and GH secretagogue receptor (GHSR) mRNA expression in the pituitary and hypothalamus did not differ between the control and treatment group. Somatostatin (SST) mRNA expression in the hypothalamus was markedly increased in the treatment group, whereas SST receptor (SSTR)-2 mRNA expression in the pituitary gland was decreased
Further studies are needed to overcome the observed desensitization to GHS.