N-acetylcysteine (NAC) and Glycine are non-essential amino acids that is showing life extension, health maintenance properties. The combination is referred to as GlyNAC or NAC-G. Therapeutic doses may not be applicable with diet.

• Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/
• A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage - https://www.frontiersin.org/articles/10.3389/fragi.2022.852569/full

Glycine is found in...

• Legumes, such as soybeans and kidney beans
• Spinach and kale

N-acetylcysteine (NAC) is found in...

• Whole grains, such as oats and wheat
• Legumes, such as lentils and chickpeas
• Garlic and onions

Three precursor substances that are needed for the synthesis of glutathione in the body:

• Cysteine: Cysteine is an amino acid that is a key building block of glutathione. It is often the limiting factor in the production of glutathione because it is not always readily available in sufficient quantities.
• Glutamic acid: Glutamic acid is another amino acid that is involved in the synthesis of glutathione. It helps to create the backbone of the glutathione molecule.
• Glycine: Glycine is the third and final amino acid involved in the synthesis of glutathione. It is used to form the peptide bonds that link the three amino acids together to create the glutathione molecule.

In addition to these three precursor substances, several enzymes are also required to convert them into glutathione. These enzymes include gamma-glutamylcysteine synthetase, glutathione synthetase, and glutathione reductase.

An ideal formula for a supplement that provides all the necessary precursors and enzymes for the production and restoration of glutathione levels in the body would include the following:

• N-acetylcysteine (NAC): NAC is a precursor to cysteine, which is a key building block of glutathione. It is also a potent antioxidant that helps to support glutathione levels in the body.
• Alpha-lipoic acid (ALA): ALA is a co-factor for several enzymes involved in glutathione production, including gamma-glutamylcysteine synthetase and glutathione synthetase. It also has antioxidant properties that help to support glutathione levels in the body.
• L-glutamine: Glutamine is another precursor to glutathione that helps to support its production in the body.
• Selenium: Selenium is a mineral that is required for the activity of glutathione peroxidase, an enzyme that helps to regenerate glutathione in the body.
• Vitamin C: Vitamin C is an antioxidant that helps to regenerate glutathione in the body by reducing oxidized glutathione back to its active form.
• Vitamin E: Vitamin E is another antioxidant that works synergistically with vitamin C to regenerate glutathione in the body.
• Zinc: Zinc is a co-factor for glutathione synthetase, an enzyme involved in glutathione production.
• Magnesium: Magnesium is required for the activity of glutathione reductase, an enzyme that helps to regenerate glutathione in the body.

By combining these ingredients in the right doses, it may be possible to create a supplement that provides the body with all the necessary precursors and enzymes to support glutathione production and restoration.

Food Sources...

• N-acetylcysteine (NAC): NAC is not found in significant amounts in food, but its precursor, cysteine, can be found in plant-based sources such as legumes (lentils, chickpeas, black beans), nuts and seeds (pistachios, sunflower seeds, pumpkin seeds), and whole grains (oats, quinoa).
• Alpha-lipoic acid (ALA): ALA can be found in small amounts in certain plant-based sources such as spinach, broccoli, and tomatoes.
• L-glutamine: Glutamine is found in plant-based sources such as beans, lentils, nuts and seeds (almonds, sunflower seeds, pumpkin seeds), and whole grains (brown rice, oats, quinoa).
• Selenium: Selenium can be found in plant-based sources such as Brazil nuts, chia seeds, sunflower seeds, and whole grains (brown rice, oats, quinoa).
• Vitamin C: Vitamin C is found in a wide range of plant-based sources including citrus fruits (oranges, lemons), berries (strawberries, raspberries), kiwifruit, papaya, mango, pineapple, guava, broccoli, spinach, and bell peppers.
• Vitamin E: Vitamin E is found in plant-based sources such as nuts and seeds (almonds, sunflower seeds, pumpkin seeds), leafy greens (spinach, kale, Swiss chard), and avocados.
• Zinc: Zinc can be found in plant-based sources such as legumes (lentils, chickpeas, black beans), nuts and seeds (cashews, pumpkin seeds, sesame seeds), and whole grains (brown rice, quinoa).
• Magnesium: Magnesium is found in plant-based sources such as leafy greens (spinach, kale, Swiss chard), nuts and seeds (almonds, cashews, pumpkin seeds), whole grains (brown rice, oats, quinoa), and legumes (lentils, black beans, chickpeas).